Hepatocellular carcinoma risk reduction associated with antiviral treatment in patients with noncirrhotic chronic hepatitis B: a systematic literature review and comparative meta-analysis
Arpan Mohanty, Alice E. Stead, Laura E. Telep, Amanda W. Singer, Tristan Curteis, Anna Zolotor, Catherine Frenette, Dona Khoshabafard, Kyle Hammond, Tom McQuaid, Robin K. Kelley · 2026
Read Hepatocellular carcinoma risk reduction associated with antiviral treatment in patients with noncirrhotic chronic hepatitis B: a systematic literature review and comparative meta-analysis by Arpan Mohanty, Alice E. Stead, Laura E. Telep, Amanda W. Singer, Tristan Curteis, Anna Zolotor, Catherine Frenette, Dona Khoshabafard, Kyle Hammond, Tom McQuaid, Robin K. Kelley (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13584341.txt.
Description
Arpan Mohanty and colleagues weigh whether antiviral drugs cut liver cancer risk in people with long-term hepatitis B who do not yet have cirrhosis. Hepatitis B affects close to 300 million people, and liver cancer can arise even before the liver scars badly. Their 2026 review screened more than two thousand records and kept 61 papers that covered 50 studies of treated and untreated patients.
In the four studies that could be compared head to head, treated patients developed liver cancer at a rate about forty percent lower than untreated patients. Cancer rates rose with longer follow-up in both groups, so the gap matters more over time. The authors say the findings support widening treatment rules to reach non-cirrhotic patients sooner, while calling for studies on when to start.
Catalog record
| CREATOR | Arpan Mohanty, Alice E. Stead, Laura E. Telep, Amanda W. Singer, Tristan Curteis, Anna Zolotor, Catherine Frenette, Dona Khoshabafard, Kyle Hammond, Tom McQuaid, Robin K. Kelley |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 165517 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |