Dose‐Escalated Upadacitinib for Refractory Myositis in Anti‐Jo‐1‐Positive Antisynthetase Syndrome: A Case Report
Yuji Kukida, Hironori Inoue, Sharika Menon · 2026
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Description
Kukida, Inoue, and Menon report dose-raised upadacitinib for stubborn muscle disease. The patient was a 33-year-old woman with anti-Jo-1 syndrome. Her myositis kept flaring as steroids were tapered. Many immune drugs and biologics had failed before. The dose rose from 15 to 30 mg per day in a flare.
Immune globulin and a brief steroid raise joined the flare care. The drug was stopped twice for fertility plans. Each stop was followed by a flare of disease. Restarting the drug restored control both times. Steroids were stopped for good by the end of follow-up.
Catalog record
| CREATOR | Yuji Kukida, Hironori Inoue, Sharika Menon |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 12 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |