Regulatory T-cell remodeling across the HBV infection–cirrhosis continuum
Yudan Fu, Yi Wang, Jiqi Ouyang, Wenliang Lv · 2026
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Description
Yudan Fu and three co-authors wrote a 2026 review on how regulatory T cells change across the course of hepatitis B infection and liver scarring. These T cells, called Tregs, brake the immune system. In early infection that braking limits liver damage, but it also blunts the attack on the virus.
In chronic infection, Tregs pile up in the liver and suppress virus-specific killer cells, helping the virus persist while limiting ongoing inflammation. As fibrosis advances, both Tregs and their Th17 counterparts grow scarce. In cirrhosis, the remaining Tregs are reprogrammed and woven into a suppressive, scar-promoting network with liver cells and other immune types. The review tracks their numbers, locations, and behavior at each stage. It also weighs the tangled balance between Tregs and Th17 cells.
Catalog record
| CREATOR | Yudan Fu, Yi Wang, Jiqi Ouyang, Wenliang Lv |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |