Spatial transcriptomics identifies a suppressive, T-cell–excluded tumor microenvironment in extramedullary myeloma∗
Nicholas E. Bingham, Julie R. Boiko, Daniel C. Jones, Daniel Wong, Tiffany Khong, Sridurga Mithraprabhu, Kathleen S. Ensbey, Anna E. Elz, Evan W. Newell, Andrew Spencer, Geoffrey R. Hill · 2026
Read Spatial transcriptomics identifies a suppressive, T-cell–excluded tumor microenvironment in extramedullary myeloma∗ by Nicholas E. Bingham, Julie R. Boiko, Daniel C. Jones, Daniel Wong, Tiffany Khong, Sridurga Mithraprabhu, Kathleen S. Ensbey, Anna E. Elz, Evan W. Newell, Andrew Spencer, Geoffrey R. Hill (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13584121.txt.
Description
Nicholas Bingham and co-authors map the tumor neighborhood in myeloma that has escaped the bone marrow, using spatial gene reading of biopsies. Such extramedullary disease runs fast and resists therapy. Its local immune landscape was almost unknown.
Plasma cell profiles varied strongly between patients. A shared cancer signature still ran through them all. Suppressive macrophages dominated the surrounding tissue. Killer T cells often wore exhaustion markers on their surface. Three neighborhood types recurred across the samples. Most tumor bulk sat in zones that exclude immune cells. That exclusion may explain why treatments fail there. The map points to new angles of attack for new drugs.
Catalog record
| CREATOR | Nicholas E. Bingham, Julie R. Boiko, Daniel C. Jones, Daniel Wong, Tiffany Khong, Sridurga Mithraprabhu, Kathleen S. Ensbey, Anna E. Elz, Evan W. Newell, Andrew Spencer, Geoffrey R. Hill |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |