Role of the cGAS-STING signaling pathway in diabetes mellitus and its complications: from mechanisms to therapeutics
Guangdong Qi, Tongxin Shang, Hualin Sun, Jie Wang, Lanxiang Hao · 2026
Read Role of the cGAS-STING signaling pathway in diabetes mellitus and its complications: from mechanisms to therapeutics by Guangdong Qi, Tongxin Shang, Hualin Sun, Jie Wang, Lanxiang Hao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13584090.txt.
Description
A review by Guangdong Qi and co-authors traces how a DNA alarm inside cells feeds the slow inflammation behind diabetes and its complications. When high blood sugar and fat stress damage mitochondria, stray DNA leaks into the cell body and trips the cGAS-STING pathway. That alarm then drives tissue harm in the heart, kidneys, eyes, feet, and blood vessels through cell death, scarring, and early ageing of cells.
The pathway also worsens insulin resistance, fat-tissue inflammation, and the failure of insulin-making cells. The authors survey blockers aimed at each step of the alarm, from small molecules to natural products, many showing promise in early models. They flag open problems too: effects vary by cell type, timing windows are unclear, and good clinical markers are missing.
Catalog record
| CREATOR | Guangdong Qi, Tongxin Shang, Hualin Sun, Jie Wang, Lanxiang Hao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 119 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |