Intra- and intertumoral discordance of Claudin-18.2: a systematic review and meta-analysis
TLM Vanneste, DIR Sánchez, S van der Mierden, MA Vollebergh, LL Kodach, J van Sandick, RGH Beets-Tan, P Snaebjornsson, Z Bodalal · 2026
Read Intra- and intertumoral discordance of Claudin-18.2: a systematic review and meta-analysis by TLM Vanneste, DIR Sánchez, S van der Mierden, MA Vollebergh, LL Kodach, J van Sandick, RGH Beets-Tan, P Snaebjornsson, Z Bodalal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583970.txt.
Description
TLM Vanneste and co-authors review how unevenly the protein Claudin-18.2 appears within and across tumors. The protein now guides targeted therapy, judged from a small tissue sample. If its level varies across one tumor, or differs between a first tumor and its spread, a single sample may mislead treatment choices.
Their 2026 paper is a systematic review and meta-analysis run under standard reporting rules. The team searched major databases for studies of variation inside primary tumors and of mismatches between primary tumors and matched metastases. Random-effects models pooled the mismatch rates across studies. The work gives doctors a clearer sense of how much a single biopsy can be trusted for this marker.
Catalog record
| CREATOR | TLM Vanneste, DIR Sánchez, S van der Mierden, MA Vollebergh, LL Kodach, J van Sandick, RGH Beets-Tan, P Snaebjornsson, Z Bodalal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |