Epigenetic plus cytokine therapy induces stem-like CD8+ T-cell reservoirs and intratumoral immune niches to overcome anti-PD-1 resistance
Christine Mall Minnar, Masaya Miyamoto, Asma Sarah Khelifa, Grace Lui, Katherine E Lothstein, Ainara Meler, Maria del Mar Maldonado, Duane H Hamilton, Lisa K Poppe, Nicholas Roller, Kenneth Canubas, George Zaki, Wiem Lassoued, Alexei Lobanov, Darryl Nousome, Richard Finney, Margaret Cam, Patrick Soo · 2026
Read Epigenetic plus cytokine therapy induces stem-like CD8+ T-cell reservoirs and intratumoral immune niches to overcome anti-PD-1 resistance by Christine Mall Minnar, Masaya Miyamoto, Asma Sarah Khelifa, Grace Lui, Katherine E Lothstein, Ainara Meler, Maria del Mar Maldonado, Duane H Hamilton, Lisa K Poppe, Nicholas Roller, Kenneth Canubas, George Zaki, Wiem Lassoued, Alexei Lobanov, Darryl Nousome, Richard Finney, Margaret Cam, Patrick Soo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583839.txt.
Description
Christine Mall Minnar and co-authors test a triple therapy for tumors that resist PD-1 blockade in a 2026 study. Gut and breast tumors in mice that shrug off standard immune therapy are the main test beds.
The mix joins PD-1 blockade with entinostat, a drug that loosens gene control, and N-803, a strong immune signal drug. Treated tumors gained stem-like killer T cells and more active killer cells. The tumor space also formed immune niches tied to response. Checks with human blood cells support the link. Readers get a plan for turning cold tumors into ones the immune system can attack.
Catalog record
| CREATOR | Christine Mall Minnar, Masaya Miyamoto, Asma Sarah Khelifa, Grace Lui, Katherine E Lothstein, Ainara Meler, Maria del Mar Maldonado, Duane H Hamilton, Lisa K Poppe, Nicholas Roller, Kenneth Canubas, George Zaki, Wiem Lassoued, Alexei Lobanov, Darryl Nousome, Richard Finney, Margaret Cam, Patrick Soo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |