Development of a heart failure with preserved ejection fraction risk prediction score in primary care settings with a high HIV prevalence
Frissiano Honwana, Julian Wolfson, Abdullahi M Ahmed, Zuofu Huang, Msimelelo Mgidlana, Olukayode Aremu, Zaayid Omar, Ntobeko Ntusi, Graeme Meintjes, Landon Myer, Jason V Baker, Mpiko Ntsekhe · 2026
Read Development of a heart failure with preserved ejection fraction risk prediction score in primary care settings with a high HIV prevalence by Frissiano Honwana, Julian Wolfson, Abdullahi M Ahmed, Zuofu Huang, Msimelelo Mgidlana, Olukayode Aremu, Zaayid Omar, Ntobeko Ntusi, Graeme Meintjes, Landon Myer, Jason V Baker, Mpiko Ntsekhe (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583814.txt.
Description
Frissiano Honwana and co-authors build a heart failure risk score for HIV-rich primary care in a 2026 study. Treated HIV raises risk of heart failure with preserved pumping. Diagnosis needs imaging and expertise scarce in primary care. Existing risk tools ignore HIV-related factors.
Data came from a South African study of over fifteen hundred adults. About two-thirds lived with HIV on long-term therapy. Roughly eight percent met the heart failure criteria. Four statistical models were compared with a forest classifier. Two regression models beat the forest on discrimination. The chosen score uses age, sex, HIV status, smoking, and clinical measures. It was rendered as a nomogram for bedside use. Internal validation checked discrimination and calibration by resampling. The authors offer a practical tool for low-resource clinics. Earlier referral of high-risk patients is the goal.
Catalog record
| CREATOR | Frissiano Honwana, Julian Wolfson, Abdullahi M Ahmed, Zuofu Huang, Msimelelo Mgidlana, Olukayode Aremu, Zaayid Omar, Ntobeko Ntusi, Graeme Meintjes, Landon Myer, Jason V Baker, Mpiko Ntsekhe |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |