BLIS study: a feasibility randomised controlled trial assessing compliance, acceptability and colonisation with different dosing regimens of the probiotic supplement Streptococcus salivarius K12 (Bactoblis) in adults in England
Christopher R Wilcox, David W Cleary, Maclyn Augustine, Rebecca Anderson, Nick Francis, Mark Lown, Michael Moore, Paul Little, Stuart C Clarke, Merlin Willcox · 2026
Read BLIS study: a feasibility randomised controlled trial assessing compliance, acceptability and colonisation with different dosing regimens of the probiotic supplement Streptococcus salivarius K12 (Bactoblis) in adults in England by Christopher R Wilcox, David W Cleary, Maclyn Augustine, Rebecca Anderson, Nick Francis, Mark Lown, Michael Moore, Paul Little, Stuart C Clarke, Merlin Willcox (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583812.txt.
Description
Christopher Wilcox and nine co-authors run a feasibility trial in 2026 of a probiotic lozenge for sore throats. The lozenge carries a friendly mouth bacterium that may crowd out the germs behind tonsillitis. Before a big trial, the team needed to know which dosing rhythm people would accept and whether the bacterium actually settles in the mouth.
Fifty-three adults with frequent sore throats took lozenges either weekly or daily for two weeks. Self-taken mouth swabs over five weeks tracked the bacterium's stay, and questionnaires gauged compliance. Return rates for full swab sets ran near two-thirds in both arms, informing how a larger trial should be run.
Catalog record
| CREATOR | Christopher R Wilcox, David W Cleary, Maclyn Augustine, Rebecca Anderson, Nick Francis, Mark Lown, Michael Moore, Paul Little, Stuart C Clarke, Merlin Willcox |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |