KAT5: the epigenetic regulator of central nervous system diseases
Xiaoming Xin, Lingjuan Wu, Meichen Liu, Tian Liu, Zihan Yuan, Liang Zhang, Tongqing Duan, Lei Zhang, Xianmin Zhu · 2026
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Description
Xiaoming Xin and eight co-authors review KAT5, an enzyme that tags histones with acetyl groups, and its roles in brain and nerve diseases. Such tags loosen chromatin and switch genes on, balanced against enzymes that remove them. KAT5, also called TIP60, also helps repair DNA, run cell cycles, and trigger cell death. When it malfunctions, several central nervous system diseases follow.
The review traces how KAT5 acts inside healthy brain cells and what goes wrong in neurological disorders. It gathers evidence linking the enzyme's failure to disease mechanisms across several conditions. Because one enzyme touches so many pathways, the authors weigh it as a possible drug target. They also map what a KAT5-based treatment strategy would need to prove. The paper gives researchers a single map of a wide and scattered literature.
Catalog record
| CREATOR | Xiaoming Xin, Lingjuan Wu, Meichen Liu, Tian Liu, Zihan Yuan, Liang Zhang, Tongqing Duan, Lei Zhang, Xianmin Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |