Precision Genome Engineering in Human Disease: Expanding Therapeutic Roles of CRISPR Technologies
Abraham Ehinomhen Ubhenin, Fatima Adis Adamude, Dickson Owoicho Ochalefu, Fatimah Anura, Clement Iorhembe Tarnande, Ibrahim Khalil Adam · 2026
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Description
CRISPR tools let scientists edit DNA with a precision that older methods could not match. Abraham Ubhenin and co-authors review how this genome engineering is moving into medicine. They cover its use against diabetes, cancer, blood disorders, brain diseases, and autoimmune conditions. Two newer forms, base editing and prime editing, get special attention: they rewrite single letters or short stretches without cutting both DNA strands, which improves accuracy and safety.
The review weighs two delivery routes. Cells can be taken out, edited, and returned, a route already promising for blood diseases. Or editors can be sent into the body, often packaged in fat droplets. The authors list what still blocks wider use: edits at wrong sites, immune reactions, poor delivery, and ethical worries about editing embryos. They call for sharper tools, strict testing, and firm rules before routine clinical use.
Catalog record
| CREATOR | Abraham Ehinomhen Ubhenin, Fatima Adis Adamude, Dickson Owoicho Ochalefu, Fatimah Anura, Clement Iorhembe Tarnande, Ibrahim Khalil Adam |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |