Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang · 2026
Read Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine by Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583234.txt.
Description
Lab-made sugar chains that mimic the coat of Salmonella germs could ground a broader vaccine, and one detail, a small acetyl decoration, proved decisive. Xingling Pan and co-authors report that finding in this 2026 study. Their three-sugar chains copy a repeating unit of the germ outer coat, with the decoration varied or removed.
The chains were attached to virus-like particles to make them visible to the immune system. The resulting vaccines drew strong sugar-specific antibody responses, and the pattern of decoration steered the quality of those antibodies. Current Salmonella vaccines cover few of the many types. A synthetic, defined antigen could cover more types at once, and this study shows the fine print that vaccine chemists must get right.
Catalog record
| CREATOR | Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |