SAV1 in Cooperation With FKBP52 Participates in Implantation
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan · 2026
Read SAV1 in Cooperation With FKBP52 Participates in Implantation by Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583225.txt.
Description
Eleven researchers in China uncover a timing switch for embryo implantation in a 2026 paper. The womb accepts an embryo only in a short window, choreographed by progesterone and estrogen. A scaffold protein from the Hippo pathway, SAV1, turns out to coordinate that timing.
Deleting the gene in womb cells stunted glands, broke receptivity, and blocked implantation. SAV1 binds a progesterone receptor helper and, through two kinases, tags it for entry into the nucleus, boosting receptor action. Without SAV1, progesterone signaling lagged and the window slipped late. Hormone treatment after delayed implantation rescued the outcome in deficient mice. The axis links growth control signaling to steroid timing.
Catalog record
| CREATOR | Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 86 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |