A Glutathione-Responsive Prodrug Nanosystem for Colorectal Cancer: Synergistic Co-Delivery of Paclitaxel and Curcumin to Combat Multidrug Resistance and Reinvent the Immunosuppressive Microenvironment
Yu Qiao, Shuai Yu, Chen Li, Dong-Dong Meng, Jia-Qi Niu, Dong-Run Yu, Xiao-Ming Wu, Hao-Xuan Wu, Wei-Tong Sun · 2026
Read A Glutathione-Responsive Prodrug Nanosystem for Colorectal Cancer: Synergistic Co-Delivery of Paclitaxel and Curcumin to Combat Multidrug Resistance and Reinvent the Immunosuppressive Microenvironment by Yu Qiao, Shuai Yu, Chen Li, Dong-Dong Meng, Jia-Qi Niu, Dong-Run Yu, Xiao-Ming Wu, Hao-Xuan Wu, Wei-Tong Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583130.txt.
Description
Yu Qiao and co-authors built a tiny drug carrier in 2026 for colorectal cancer. Cancer care there is trapped in a cycle: gut imbalance feeds swelling, which helps tumours hide from the immune system and resist drugs. Their carrier delivers two drugs together to the tumour.
The carrier releases its load where a tumour chemical is high. One drug is bound into the carrier skin, the other sits inside. In tests, the system beat drug pumps that push drugs out, and it restored gut balance. It also cut swelling signals, drew in killer immune cells, and cut calming ones. The authors offer it as a new route for hard-to-treat cases.
Catalog record
| CREATOR | Yu Qiao, Shuai Yu, Chen Li, Dong-Dong Meng, Jia-Qi Niu, Dong-Run Yu, Xiao-Ming Wu, Hao-Xuan Wu, Wei-Tong Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |