Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang · 2026
Read Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy by Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583125.txt.
Description
Haitao Zhao and co-authors review lab-grown tumor models built on tiny scaffolds, in a 2026 paper. Flat cell cultures and animal tests often fail to copy a real tumor's shape, stiffness, and mix of cells, so drug results can mislead. Scaffold models plant cancer cells in engineered materials that mimic the tumor's home ground. The review sorts the field and weighs where it is heading.
The authors cover natural and man-made scaffold stuffs, plus ground taken from real tissue with its cells stripped out. They show how designs copy low oxygen, stiffness, and cell cross-talk. Uses span drug screening, personal medicine, and spread studies. Hurdles named include shared standards and scale-up, with smart materials and 4D printing as next steps.
Catalog record
| CREATOR | Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 198 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |