Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice
Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang · 2026
Read Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice by Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583120.txt.
Description
Longping Yao and co-authors trace a pathway that links a Parkinson's gene to depression in mice in a study from 2026. The gene variant is LRRK2 G2019S, a known cause of Parkinson's disease. Mice with the variant show depression-like behavior, but the chain of causes was unclear.
From about twenty-five weeks of age, the mice showed strong depressive-like signs. A brain growth factor, GDNF, fell in the hippocampus, while star-shaped support cells fired up with inflammation. Energy supply in cells dropped, and nerve cells died at higher rates. A drug that blocks LRRK2 reversed these changes. Gene scans pointed to broken links between energy and signaling systems.
Catalog record
| CREATOR | Longping Yao, Maryam Hatami, Sumeyye Koc, Qing Jiang, Thomas Skutella, Yuanfeng Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |