Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li · 2026
Read Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets by Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583112.txt.
Description
Xinjie Lin, Yangchang Zhang, Yang Pu, and sixteen colleagues mine blood proteins for clues to a lethal lung disease in this two thousand twenty-six study. Idiopathic pulmonary arterial hypertension lacks specific markers. The team measured nearly three thousand plasma proteins in over forty-four thousand UK Biobank participants. About four hundred had the disease. They combined standard association tests with genetic Mendelian randomization to separate likely causes from bystanders.
Eighteen proteins carried both kinds of support; twelve survived checks across ancestries and sensitivity tests. Together they defined a high-death subtype marked by vessel and heart remodeling. Models combining clinical data with proteins predicted new cases and death with areas under the curve near zero point seven eight. Protein contributions differed between men and women. Six proteins linked to existing drugs, including one pairing a protein called ANXA2 with the drug Artenimol as a candidate for reuse.
Catalog record
| CREATOR | Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |