Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman · 2026
Read Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease by Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13583081.txt.
Description
Dorothea Böken and co-authors map partners of tau clumps across Alzheimer's stages in a 2026 study. Tau takes many forms, from single units to small loose clumps to mature fibers. Which cell parts cling to each form was poorly known.
Using post-mortem brain tissue, the team pulled down each form and read its protein partners. Small clumps drew guard and immune proteins, while fibers drew frame, fuel, and RNA proteins. Fine imaging confirmed the split for key partners. A neuron model with fast clumping echoed the brain pattern. Time-ordered reads show the partner web reshapes as disease advances, which exposes stage-tied weak points.
Catalog record
| CREATOR | Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |