Exosomal LINC00323 accelerates angiogenesis through activating the MAPK and JAK-STAT pathways by stabilizing CDC5L in NSCLC
Bin Ke, Hai Zhong, Xiaofei Chen, Lijun He, Chenxin Yan, Jianjun Li, Lin Shi · 2026
Read Exosomal LINC00323 accelerates angiogenesis through activating the MAPK and JAK-STAT pathways by stabilizing CDC5L in NSCLC by Bin Ke, Hai Zhong, Xiaofei Chen, Lijun He, Chenxin Yan, Jianjun Li, Lin Shi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13582790.txt.
Description
Bin Ke and colleagues present a 2026 study of a long RNA strand called LINC00323 in non-small cell lung cancer, the most common form of lung cancer. The strand is found at high levels in tumors, and patients with more of it tend to do worse. The group asked how it helps tumors grow and form new blood vessels, a process tumors need to feed themselves.
Tests on tumor tissue and on lung cancer cells showed that raising LINC00323 sped up cell growth and vessel growth, while lowering it slowed both. The strand works by holding on to a protein named CDC5L and keeping it stable, which switches on two growth pathways. Tiny parcels sent out by cancer cells also carried the strand to vessel-lining cells.
Catalog record
| CREATOR | Bin Ke, Hai Zhong, Xiaofei Chen, Lijun He, Chenxin Yan, Jianjun Li, Lin Shi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71613 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |