Transcriptome-based epigenetic screening identifies DNA hypermethylation signatures as prognostic biomarkers in oral squamous cell carcinoma
Yu Kyeong Han, Jihye Park, Hye Su Han, Keunsoo Kang, Hae Ryoun Park, Joo Mi Yi · 2026
Read Transcriptome-based epigenetic screening identifies DNA hypermethylation signatures as prognostic biomarkers in oral squamous cell carcinoma by Yu Kyeong Han, Jihye Park, Hye Su Han, Keunsoo Kang, Hae Ryoun Park, Joo Mi Yi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13582760.txt.
Description
Yu Kyeong Han and five co-authors hunted for chemical silencing marks on DNA that predict outcomes in oral cancer, in a 2026 study. In oral squamous cell carcinoma, extra methyl groups often shut genes off, but the full pattern and its link to survival were unclear. The team used a drug that strips methylation, then sequenced which genes woke up in cancer cell lines.
Five genes showed cancer-specific silencing by methylation, confirmed in tumor samples and in a large public dataset. One of them, CTGF, predicted poor survival on its own in two separate cohorts. A combined signature using CTGF plus another gene, ANG, performed even better. The authors propose these marks as practical prognostic biomarkers.
Catalog record
| CREATOR | Yu Kyeong Han, Jihye Park, Hye Su Han, Keunsoo Kang, Hae Ryoun Park, Joo Mi Yi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |