Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes
Elena Müller-Limberger, Bettina Frederick, Sebastian Hansen, Maria Wohlfarth, Ruth Janoschek, Esther Mahabir, Pascal Fischer, Dirk Gründemann, Simone Kalis, Miguel A Alejandre Alcázar, Jörg Dötsch, Eva Hucklenbruch-Rother, Sarah Appel · 2026
Read Maternal metformin treatment in obese pregnant dams normalizes neonatal sensory-motor reflexes by Elena Müller-Limberger, Bettina Frederick, Sebastian Hansen, Maria Wohlfarth, Ruth Janoschek, Esther Mahabir, Pascal Fischer, Dirk Gründemann, Simone Kalis, Miguel A Alejandre Alcázar, Jörg Dötsch, Eva Hucklenbruch-Rother, Sarah Appel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13582716.txt.
Description
Elena Müller-Limberger and co-authors test metformin treatment in obese pregnant mice in a study from two thousand twenty-six. The drug, used for diabetes, may improve the mother's metabolism and help early development of offspring. Mouse mothers were fed a Western-style diet before and during pregnancy.
A treated group got the drug in drinking water during gestation. At mid-pregnancy, treated mothers sat between obese and lean groups on several measures, without clear statistical gaps. The drug did not change pup survival but sped early weight gain. Reflex development in pups, such as righting and slope responses, matured faster than in untreated obese litters. The authors say benefits showed most clearly in the newborn reflexes.
Catalog record
| CREATOR | Elena Müller-Limberger, Bettina Frederick, Sebastian Hansen, Maria Wohlfarth, Ruth Janoschek, Esther Mahabir, Pascal Fischer, Dirk Gründemann, Simone Kalis, Miguel A Alejandre Alcázar, Jörg Dötsch, Eva Hucklenbruch-Rother, Sarah Appel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |