Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation
Gaojie Zhang, Ye Huang, Zizhen Gong, Congfeng Xu, Xianglin Ding, Wei Cai, Jin Wu · 2026
Read Multi-omics analyses unveil gut microbiota and metabolites signatures in deoxycholic acid-associated intestinal inflammation by Gaojie Zhang, Ye Huang, Zizhen Gong, Congfeng Xu, Xianglin Ding, Wei Cai, Jin Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13582423.txt.
Description
Zhang, Huang, Gong and colleagues traced how excess deoxycholic acid, a bile acid raised by high-fat diets, drives gut inflammation in mice in 2026. Mice received 0.2 percent deoxycholic acid for 12 weeks, and the team profiled gut microbes and faecal metabolites while checking colon tissue damage.
The acid cut microbial diversity and raised inflammatory signals such as TNF-alpha, IL-6 and IL-1 beta. Bacteroides and Desulfovibrio stood out as markers of exposure, while helpful species and their anti-inflammatory metabolites fell. Other bile acid metabolites rose. The linked microbe and metabolite patterns help explain how a high-fat diet can fuel bowel inflammation.
Catalog record
| CREATOR | Gaojie Zhang, Ye Huang, Zizhen Gong, Congfeng Xu, Xianglin Ding, Wei Cai, Jin Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |