Pre-treatment serum extracellular vesicle-enriched microbiome profiles and SSRI treatment response in obsessive-compulsive disorder: a prospective naturalistic cohort study
Jee In Kang, Chun Il Park, June-Ho Seo, Chil-sung Kang, Yoon-Keun Kim, Se Joo Kim · 2026
Read Pre-treatment serum extracellular vesicle-enriched microbiome profiles and SSRI treatment response in obsessive-compulsive disorder: a prospective naturalistic cohort study by Jee In Kang, Chun Il Park, June-Ho Seo, Chil-sung Kang, Yoon-Keun Kim, Se Joo Kim (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13582318.txt.
Description
Jee In Kang and colleagues tested serum microbe profiles as predictors of antidepressant response. Their 2026 cohort study covers obsessive-compulsive disorder patients starting SSRIs. Microbes may shape brain-body signals that affect treatment results. Blood carries bacterial vesicles whose cargo reflects the microbiome. Samples were drawn before any drug treatment began.
Thirty-two patients were tracked for twelve weeks of therapy. Response meant a large drop on a standard symptom scale. Baseline vesicle microbe patterns were compared between outcome groups. The drug-free start kept the measures clean of treatment effects. A predictive profile could guide earlier therapy switches. Non-responders now wait months before plans change. The study joins psychiatry with microbiome science.
Catalog record
| CREATOR | Jee In Kang, Chun Il Park, June-Ho Seo, Chil-sung Kang, Yoon-Keun Kim, Se Joo Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |