Live auxotrophic vaccines contribute to protection against chronic lung infections caused by Pseudomonas aeruginosa in C57BL/6 mice
Víctor Fuentes-Valverde, Alexandra Correia, Patricia García, Elena Pérez-Antón, Irina Amorim, Soraya Rumbo-Feal, Maria P. Cabral, Manuel Vilanova, Miriam Moscoso, Germán Bou · 2026
Read Live auxotrophic vaccines contribute to protection against chronic lung infections caused by Pseudomonas aeruginosa in C57BL/6 mice by Víctor Fuentes-Valverde, Alexandra Correia, Patricia García, Elena Pérez-Antón, Irina Amorim, Soraya Rumbo-Feal, Maria P. Cabral, Manuel Vilanova, Miriam Moscoso, Germán Bou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13582316.txt.
Description
Victor Fuentes-Valverde and nine co-authors tested a living vaccine against a stubborn lung germ in a 2026 mouse study. The bacterium causes chronic lung infections, often drug-resistant, above all in people with cystic fibrosis. Their vaccine strain is alive but crippled: it lacks the ability to make one building block and so cannot thrive in the body.
Mice got the vaccine through the nose or skin, in two or three doses. A strong two-dose nose regimen protected against sudden infection but caused brief weight loss. A gentler three-dose plan kept the benefit with less harm. Vaccinated mice made strong immune signals of the right kinds. When later exposed to the slimy strains that settle in lungs, they carried fewer bacteria. The authors say such weakened live vaccines could soften chronic infections in patients.
Catalog record
| CREATOR | Víctor Fuentes-Valverde, Alexandra Correia, Patricia García, Elena Pérez-Antón, Irina Amorim, Soraya Rumbo-Feal, Maria P. Cabral, Manuel Vilanova, Miriam Moscoso, Germán Bou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |