Comparative analysis of biologic drug effects and distal particulate embolization among three drug-coated balloons: a histological and biological study in a rabbit model
Kazuki Aihara, Sho Torii, Manabu Shiozaki, Yu Sato, Kaho Hashimoto, Daiki Suzuki, Ryosuke Ohmura, Yuto Ono, Yuki Matsumoto, Norihito Nakamura, Yuji Ikari, Gaku Nakazawa · 2026
Read Comparative analysis of biologic drug effects and distal particulate embolization among three drug-coated balloons: a histological and biological study in a rabbit model by Kazuki Aihara, Sho Torii, Manabu Shiozaki, Yu Sato, Kaho Hashimoto, Daiki Suzuki, Ryosuke Ohmura, Yuto Ono, Yuki Matsumoto, Norihito Nakamura, Yuji Ikari, Gaku Nakazawa (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13582060.txt.
Description
Kazuki Aihara and colleagues compared three drug-coated balloons in rabbits, asking which delivers drug to the artery with the least downstream harm. Coated balloons help leg arteries, but drug particles washing downstream can injure distant muscle, a worry in severe limb disease. Their 2026 study gave 18 rabbits aorta balloon treatment with Ranger, IN.PACT Admiral, or Luminor devices, then checked treated arteries and downstream leg muscle at 28 days.
Drug levels at the target and muscle-cell loss there were similar across devices. Downstream, however, Luminor left far more drug in muscle and the worst particle embolisation, followed by IN.PACT, with Ranger lowest. The authors conclude that the low-dose Ranger device pairs strong local delivery with lower downstream risk, while clinical studies must confirm limb outcomes.
Catalog record
| CREATOR | Kazuki Aihara, Sho Torii, Manabu Shiozaki, Yu Sato, Kaho Hashimoto, Daiki Suzuki, Ryosuke Ohmura, Yuto Ono, Yuki Matsumoto, Norihito Nakamura, Yuji Ikari, Gaku Nakazawa |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |