Spatial membrane lipid remodelling encodes epithelial lineage and state in human colon cancer
Ramon M Rodriguez, Karim Pérez-Romero, Albert Maimó-Barceló, Teresa Ximelis, Cristina Huergo-Baños, Marcos A Martínez, Juan José Segura-Sampedro, Rafael Morales-Soriano, Cristina Pineño-Flores, Álvaro García-Granero, Sebastián Jerí, Ana M Aransay, José A Fernández, Gwendolyn Barceló-Coblijn · 2026
Read Spatial membrane lipid remodelling encodes epithelial lineage and state in human colon cancer by Ramon M Rodriguez, Karim Pérez-Romero, Albert Maimó-Barceló, Teresa Ximelis, Cristina Huergo-Baños, Marcos A Martínez, Juan José Segura-Sampedro, Rafael Morales-Soriano, Cristina Pineño-Flores, Álvaro García-Granero, Sebastián Jerí, Ana M Aransay, José A Fernández, Gwendolyn Barceló-Coblijn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581992.txt.
Description
Ramon Rodriguez and co-authors map how the fat makeup of cell walls varies across human colon tumors, in work from 2026. Tumors are patchworks of cell states, and that patchwork drives how cancer grows. Gene maps of tumors have advanced fast, while fat maps have lagged.
The team joined fat imaging with gene-based cell state maps on matched slices of tumor tissue. Samples came from first tumors and from spread tumors in the belly. They found four fat patterns in the surface cell layer, each sorted by place in the tissue. Those patterns lined up with gene programs for cell lineage and maturity. A second patient group backed the patterns. The work ties wall fat to what a cancer cell is and does.
Catalog record
| CREATOR | Ramon M Rodriguez, Karim Pérez-Romero, Albert Maimó-Barceló, Teresa Ximelis, Cristina Huergo-Baños, Marcos A Martínez, Juan José Segura-Sampedro, Rafael Morales-Soriano, Cristina Pineño-Flores, Álvaro García-Granero, Sebastián Jerí, Ana M Aransay, José A Fernández, Gwendolyn Barceló-Coblijn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |