The circadian–melatonin axis in breast cancer metastasis: molecular mechanisms, organ-specific metastatic niches, and therapeutic opportunities
Ching-Hsiang Wang, Kian-Hwee Chong, Ching-Feng Cheng, Yao-Jen Chang, Kuo-Wang Tsai · 2026
Read The circadian–melatonin axis in breast cancer metastasis: molecular mechanisms, organ-specific metastatic niches, and therapeutic opportunities by Ching-Hsiang Wang, Kian-Hwee Chong, Ching-Feng Cheng, Yao-Jen Chang, Kuo-Wang Tsai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581893.txt.
Description
Wang and four co-authors wrote a review in twenty twenty-six on body clocks, melatonin, and breast cancer spread. Spread of this cancer is the main cause of death from the disease. Melatonin is a hormone tied to the daily sleep-wake cycle. The review gathers proof that clock disruption and melatonin shape how tumors spread. It covers effects on cell shape shifts, stem-like traits, and cells that ride the blood. It also covers tumor fuel use and immune changes.
The authors discuss how melatonin may shape the spots where spread takes hold. Those spots include bone, lung, liver, and brain tissue. They weigh timed treatment and added melatonin as care options. Proof from patients is still thin, they note. They call for trials that build clock data into treatment plans.
Catalog record
| CREATOR | Ching-Hsiang Wang, Kian-Hwee Chong, Ching-Feng Cheng, Yao-Jen Chang, Kuo-Wang Tsai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |