Thirty years in, regulatory T cells are ready for medicine
Ryoji Kawakami, Ayush Jain · 2026
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Description
Thirty years after their discovery, regulatory T cells are moving from laboratory curiosity to medicine. Kawakami and Jain review the arc of this immune cell type, which exists to keep the immune system from attacking the body itself.
These cells enforce tolerance through a kit of suppressive molecules, all orchestrated by the master switch FoxP3. When they fail, autoimmunity, chronic inflammation, and cancer follow. The review revisits the 1995 discovery of the CD25-marked population and the decades of work that explained how dominant tolerance works. It then turns to therapy: attempts to boost or borrow these cells against immune disease, the hurdles that remain, and new technologies pushing them toward the clinic.
Catalog record
| CREATOR | Ryoji Kawakami, Ayush Jain |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |