IL-5/IL-5R blockade enables safe non-steroidal anti-inflammatory agent reintroduction in non-steroidal anti-inflammatory exacerbated respiratory disease
Pelin Korkmaz, Nevzat Kahveci, Semra Demir, Osman Ozan Yegit, Derya Unal, Merve Hormet Igde, Mehmet E. Sezgin, Ayse F. Aslan, Bircan Erden, Leyla Bolek, Merve D. Atasever, Selin E. Guzel, Şule Çelik Kamacı, Esra Kaya, Aslı Gelincik · 2026
Read IL-5/IL-5R blockade enables safe non-steroidal anti-inflammatory agent reintroduction in non-steroidal anti-inflammatory exacerbated respiratory disease by Pelin Korkmaz, Nevzat Kahveci, Semra Demir, Osman Ozan Yegit, Derya Unal, Merve Hormet Igde, Mehmet E. Sezgin, Ayse F. Aslan, Bircan Erden, Leyla Bolek, Merve D. Atasever, Selin E. Guzel, Şule Çelik Kamacı, Esra Kaya, Aslı Gelincik (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581757.txt.
Description
Pelin Korkmaz and co-authors report a 2026 study on patients whose airways worsen when they take common pain drugs such as aspirin. These patients often also have asthma and nasal polyps. Drugs that block a signal called IL-5 are known to help the asthma and polyps, but whether they restore tolerance to the pain drugs was unclear.
After treatment with the blocking drugs, patients showed far fewer of the target blood cells, much better asthma control scores, and better nose and quality-of-life scores. Repeat aspirin challenge tests turned positive in far fewer patients, and all patients could step down their inhaled drug dose. The four who stayed intolerant reacted later, at higher doses, and more mildly. The authors see a real shift in the disease pattern.
Catalog record
| CREATOR | Pelin Korkmaz, Nevzat Kahveci, Semra Demir, Osman Ozan Yegit, Derya Unal, Merve Hormet Igde, Mehmet E. Sezgin, Ayse F. Aslan, Bircan Erden, Leyla Bolek, Merve D. Atasever, Selin E. Guzel, Şule Çelik Kamacı, Esra Kaya, Aslı Gelincik |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |