Innate immune activation profiles are associated with polarization of the T cell response to recombinant arenaviral vectors
Sarah Szaffich, Valentin Just, Natalija Cvetkovic, Naila Pepic, Michael Schwendinger, Kia Katchar, Klaus K. Orlinger, Henning Lauterbach, Josipa Raguz, Katell Bidet Huang · 2026
Read Innate immune activation profiles are associated with polarization of the T cell response to recombinant arenaviral vectors by Sarah Szaffich, Valentin Just, Natalija Cvetkovic, Naila Pepic, Michael Schwendinger, Kia Katchar, Klaus K. Orlinger, Henning Lauterbach, Josipa Raguz, Katell Bidet Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581738.txt.
Description
Sarah Szaffich and co-authors study, in a 2026 paper, how the first wave of immune activation shapes the T cell response to cancer vaccine vectors built from arenaviruses. Such vectors are prized for raising durable T cell responses against tumors, a central challenge in cancer immunotherapy. The two vectors here were engineered from two different arenaviruses.
Both carry a fused protein built from two proteins of a cancer linked virus, HPV16. One vector alone, or the pair together, raised strong and lasting killer T cell responses in patients with HPV linked cancers. The parent viruses, though in one family, are distant kin, so they meet the body differently. Earlier work showed both infect and activate professional antigen presenting cells. This study links the pattern of that early activation to how the later T cell response polarizes, a clue for tuning future vectors.
Catalog record
| CREATOR | Sarah Szaffich, Valentin Just, Natalija Cvetkovic, Naila Pepic, Michael Schwendinger, Kia Katchar, Klaus K. Orlinger, Henning Lauterbach, Josipa Raguz, Katell Bidet Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |