SYTL5 drives malignant progression in differentiated thyroid carcinoma: unveiling its regulatory mechanisms
Xiaohui Zhu, Xia Pan, Dongmei Jiang, Hengfeng Cui, Haiyan Wu, Yuying Wang, Xia Li · 2026
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Description
Xiaohui Zhu and six colleagues pinned a gene called SYTL5 as a driver of spread in the most common form of thyroid cancer. They checked the gene in 107 pairs of tumor and healthy tissue from the same patients. The gene was switched on far more in tumors, and high levels tracked with spread to neck lymph nodes. Cell lines with the gene dimmed or boosted let the team test cause, not just correlation.
Cells with extra SYTL5 grew, moved, and invaded more; cells with it dimmed slowed and died more. Tumors grown in mice told the same story. A second factor, ZNF384, was shown to switch the gene on at its promoter. The twenty twenty-six study marks SYTL5 as both a warning sign and a drug target in thyroid cancer, and names the switch that turns it up.
Catalog record
| CREATOR | Xiaohui Zhu, Xia Pan, Dongmei Jiang, Hengfeng Cui, Haiyan Wu, Yuying Wang, Xia Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |