Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice
Mariana Araujo Oliveira, Ywa Perpétuo Socorro Toda Tavares, Renata Chaves Albuquerque, Silene Migliorini, Sandro Rogério Almeida, Joilson O. Martins · 2026
Read Diabetes impairs antifungal immunity and drives fatal disseminated sporotrichosis in mice by Mariana Araujo Oliveira, Ywa Perpétuo Socorro Toda Tavares, Renata Chaves Albuquerque, Silene Migliorini, Sandro Rogério Almeida, Joilson O. Martins (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581713.txt.
Description
Mariana Oliveira and five co-authors show that diabetes turns a fungal infection fatal in mice. The fungus Sporothrix brasiliensis causes sporotrichosis, which is usually limited. The team builds a type 1 diabetes mouse model and compares infected diabetic mice with infected controls with normal blood sugar.
Diabetic mice develop progressive ulcerative lesions and spread of fungus to lymph nodes, liver, and brain, with full mortality. Blood signals show high levels of three inflammatory proteins and low counts of a key T cell type in the spleen. Immune cells from diabetic hosts first bind yeast strongly, then fail fast, a sign of exhaustion. Liver markers suggest a late stage block in cellular cleanup. The model maps how diabetes weakens antifungal defense.
Catalog record
| CREATOR | Mariana Araujo Oliveira, Ywa Perpétuo Socorro Toda Tavares, Renata Chaves Albuquerque, Silene Migliorini, Sandro Rogério Almeida, Joilson O. Martins |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |