Early pharmacologic venous thromboembolism prophylaxis and in-hospital mortality in ICU patients with intracerebral hemorrhage: a landmark, propensity-weighted cohort study
Hongfu Chen, Jianyong Ji, Hui Zhang, Er Nie, Qing Lan · 2026
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Description
Hongfu Chen and co-authors published this cohort study in 2026. Patients with bleeding inside the brain face a dilemma: blood thinners prevent dangerous clots in the veins, but might worsen the bleeding. Timing is the open question. Using an intensive care database, the team compared patients who started preventive blood thinners within forty-eight hours against those who did not. Their design fixed patient status at a two-day landmark and statistically balanced the groups.
The analysis covered 2,380 patients. Death in hospital occurred in 10.8 percent of the early group and 17.4 percent of the rest. After adjustment, early prevention carried twenty-eight percent lower odds of death. Rates of vein clots did not differ significantly. Most checks of the analysis pointed the same way. The authors note that missing brain-scan details could bias the result. Even so, the findings support starting prevention early rather than waiting.
Catalog record
| CREATOR | Hongfu Chen, Jianyong Ji, Hui Zhang, Er Nie, Qing Lan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |