Connective tissue disorders and cardiac arrhythmias: genetic pathways, mechanistic bridges, and clinical implications
Luke Dreher, Hussein Abdul Nabi, Ramzi Ibrahim, Mahmoud Abdelnabi, Omar Baqal, Christopher N. Kanaan, Min Choon Tan, Linnea M. Baudhuin, Fadi E. Shamoun, Hicham Z. El Masry · 2026
Read Connective tissue disorders and cardiac arrhythmias: genetic pathways, mechanistic bridges, and clinical implications by Luke Dreher, Hussein Abdul Nabi, Ramzi Ibrahim, Mahmoud Abdelnabi, Omar Baqal, Christopher N. Kanaan, Min Choon Tan, Linnea M. Baudhuin, Fadi E. Shamoun, Hicham Z. El Masry (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581506.txt.
Description
Luke Dreher and co-authors reviewed in 2026 how connective tissue disorders can disturb heart rhythm. Disorders such as Marfan syndrome and the Ehlers-Danlos group are known for weak vessels and aorta problems. Growing evidence shows they also raise the risk of atrial and ventricular rhythm faults, often without clear muscle or valve disease.
The review draws together data on the tissue changes that set up those faults. It stresses four bridges. One is widespread heart scarring driven by a growth signal. Others are valve and ring faults such as mitral prolapse, and altered force sensing that links loose matrix to cell signaling. Gene routes behind the disorders are mapped as well. Readers get a guide for spotting rhythm risk in patients often watched only for aorta trouble.
Catalog record
| CREATOR | Luke Dreher, Hussein Abdul Nabi, Ramzi Ibrahim, Mahmoud Abdelnabi, Omar Baqal, Christopher N. Kanaan, Min Choon Tan, Linnea M. Baudhuin, Fadi E. Shamoun, Hicham Z. El Masry |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |