Calmodulin controls spatial and temporal specificity of calcium-induced calcium release
Joanna Jędrzejewska-Szmek, Kim T. Blackwell, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin · 2026
Read Calmodulin controls spatial and temporal specificity of calcium-induced calcium release by Joanna Jędrzejewska-Szmek, Kim T. Blackwell, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581220.txt.
Description
Joanna Jedrzejewska-Szmek and Kim Blackwell model how a common brain protein, calmodulin, keeps calcium signals in nerve cells tight and brief. Calcium bursts help form memories, but loose calcium control is tied to Alzheimer's disease and aging. Their 2026 study builds a detailed model of a nerve branch with its internal calcium store.
When the protein's brake on a release channel weakens, calcium signals spread wider and last longer in the model. In an aged setting, freeing half the channels doubled the spread. A separate pump effect, not the channel, raised resting calcium as seen in the disease. The work links small protein changes to signal changes that could harm learning and memory.
Catalog record
| CREATOR | Joanna Jędrzejewska-Szmek, Kim T. Blackwell, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin, Ausra Saudargiene, Andrea E. Martin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 102 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |