Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments
Marina M. Watowich, Rachel M. Petersen, Layla Brassington, Audrey M. Arner, Grace Rodenberg, Tan Bee Ting A/P Tan Boon Huat, Kar Lye Tam, Em Schellenberg, Izandis bin Mohd Sayed, Echwa John, John C. Kahumbu, Benjamin Muhoya, Michael Gurven, Benjamin C. Trumble, Sospeter Ngoci Njeru, Dino Martins, Ju · 2026
Read Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments by Marina M. Watowich, Rachel M. Petersen, Layla Brassington, Audrey M. Arner, Grace Rodenberg, Tan Bee Ting A/P Tan Boon Huat, Kar Lye Tam, Em Schellenberg, Izandis bin Mohd Sayed, Echwa John, John C. Kahumbu, Benjamin Muhoya, Michael Gurven, Benjamin C. Trumble, Sospeter Ngoci Njeru, Dino Martins, Ju (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581214.txt.
Description
Marina Watowich and a large team compare the effects of a gene variant across industrialized and non-industrial settings, in a 2026 study. The variant, a form of the APOE gene, changes fat and immune biology. It raises risk of brain and heart disease in industrialized settings, yet it is the ancestral human form and has persisted.
One idea is that its costs and benefits differed in past environments. High pathogen load, high activity, or low-fat diets may soften its harms, and gains for fertility have been reported. The team test these ideas directly across settings. The work asks how environment flips a gene's effects.
Catalog record
| CREATOR | Marina M. Watowich, Rachel M. Petersen, Layla Brassington, Audrey M. Arner, Grace Rodenberg, Tan Bee Ting A/P Tan Boon Huat, Kar Lye Tam, Em Schellenberg, Izandis bin Mohd Sayed, Echwa John, John C. Kahumbu, Benjamin Muhoya, Michael Gurven, Benjamin C. Trumble, Sospeter Ngoci Njeru, Dino Martins, Ju |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |