Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis
Deepak Arya, Kati Tormanen, Jay J. Oh, Shaohui Wang, Homayon Ghiasi, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones · 2026
Read Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis by Deepak Arya, Kati Tormanen, Jay J. Oh, Shaohui Wang, Homayon Ghiasi, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13581205.txt.
Description
Herpes simplex virus talks its way into cells through a handshake between its surface protein gD and a host receptor called HVEM, a conversation that also steers latency and immune signaling. Deepak Arya and co-authors finally gain a clean way to break that handshake in a 2026 study. Systematic mutations pinpointed three amino acids that the binding cannot do without.
A triple mutant blocked the interaction more completely than a single change. The team then built viruses carrying each version and compared their growth with the wild type. Replication held up in four mammalian cell lines, with one neural line the exception. Engineered viruses that cannot touch one receptor let researchers separate its jobs in entry, latency, and immune control.
Catalog record
| CREATOR | Deepak Arya, Kati Tormanen, Jay J. Oh, Shaohui Wang, Homayon Ghiasi, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones, Robert Kalejta, Clinton Jones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |