Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice
Chloe I Rybicki‐Kler, Isla A W Brooks, Izabela Jedrasiak‐Cape, Tao Deng, Cassandra Avila, Elizabeth Brouns, Alex Lekander, Omar J Ahmed · 2026
Read Reciprocal molecular and cellular cholinergic working memory impairments in Alzheimer's disease model mice by Chloe I Rybicki‐Kler, Isla A W Brooks, Izabela Jedrasiak‐Cape, Tao Deng, Cassandra Avila, Elizabeth Brouns, Alex Lekander, Omar J Ahmed (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13580843.txt.
Description
Chloe Rybicki-Kler and co-authors study in a 2026 mouse work how a memory circuit loses its chemical support in Alzheimer's disease. A set of brain cells sends acetylcholine to a cortex zone that holds working memory, by keeping neurons firing after a cue fades. The team read genes and firing in that zone in a disease model.
Cholinergic inputs had thinned, a key receptor gene had faded, and the after-firing was weak. The paired loss hints that drugs meant to boost that receptor may miss their target cells. Memory aids may need to guard the input cells as well.
Catalog record
| CREATOR | Chloe I Rybicki‐Kler, Isla A W Brooks, Izabela Jedrasiak‐Cape, Tao Deng, Cassandra Avila, Elizabeth Brouns, Alex Lekander, Omar J Ahmed |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |