Sex‐Related Differences in Physiologically‐Based Biopharmaceutics Modeling
Marianela Chavarría‐Rojas, Mubtasim Murshed, Marianela Lorier, Nikoletta Fotaki, Manuel Ibarra · 2026
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Description
Chavarría-Rojas and colleagues audit the software that predicts how drugs move through the body, asking whether its virtual women are built from female physiology. Sex changes stomach acidity, gut speed, and body makeup, so absorption can differ by sex. Their 2026 study reviews three platforms for sex specific gut settings. It builds models of the painkiller ketoprofen in men and stretches them to women, first with default settings and then with gut values refined for women.
All three platforms included sex differences in anatomy but skipped sex specific gut details. With default female settings, the models overshot drug levels, understated the time to peak, and produced curves identical to men's, erasing differences. Feeding in corrected gut transit values brought the predictions in line with observed data. The fix, the authors conclude, is in users' hands: default virtual populations need tuning before sex claims from a model can be trusted.
Catalog record
| CREATOR | Marianela Chavarría‐Rojas, Mubtasim Murshed, Marianela Lorier, Nikoletta Fotaki, Manuel Ibarra |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |