Metabolic Exhaustion, p38 MAPK/Rac1 GTPase/MLKL Signaling, and Ca2+ Influx Mediate Solasodine-Triggered Eryptosis
Iman A ALAJEYAN, Jawaher ALSUGHAYYIR, Mohammad A ALFHILI · 2026
Read Metabolic Exhaustion, p38 MAPK/Rac1 GTPase/MLKL Signaling, and Ca2+ Influx Mediate Solasodine-Triggered Eryptosis by Iman A ALAJEYAN, Jawaher ALSUGHAYYIR, Mohammad A ALFHILI (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13580678.txt.
Description
Alajeyan and colleagues examined whether solasodine, a plant compound from nightshade-family foods that is being studied against cancer, also harms healthy red blood cells. Their 2026 laboratory study used red cells from healthy volunteers and tested for eryptosis, the programmed death of red blood cells that can contribute to anemia during chemotherapy.
Alajeyan found that solasodine triggered modest red cell rupture alongside clear death signals, including surface changes that flag cells for removal, cell swelling, and spiky cell shapes. Supplying energy fuels such as ATP reversed much of the damage, as did removing calcium from the fluid around the cells. Several targeted blockers also protected the cells, and the death process needed three signaling proteins working together. The results warn that solasodine's cell-killing power is not cancer-specific and suggest protective add-ons for future drug development.
Catalog record
| CREATOR | Iman A ALAJEYAN, Jawaher ALSUGHAYYIR, Mohammad A ALFHILI |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |