Hydrogen Sulfide Suppresses RANKL-Induced Osteoclast Differentiation by Modulating Nrf2/GPX4 Signaling
Zelin HUANG, Ming LAI, Qinglan WEI, Qi CAO, Kang CHEN, Jie ZHANG · 2026
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Description
Huang and colleagues tested whether hydrogen sulfide can slow the formation of osteoclasts, the cells that break down bone. Hydrogen sulfide is a gas the body makes in small amounts, and it also calms cell damage. Excess osteoclast activity drives diseases where bone is eaten away. Their 2026 laboratory study used a mouse cell line pushed toward becoming osteoclasts by a signal protein called RANKL.
Huang added a hydrogen sulfide donor at several strengths and measured bone-eating cell formation, stress damage, and cell powerhouses. The treatment sharply reduced osteoclast formation and lowered marker proteins for bone breakdown, while easing oxidative stress, meaning damage from reactive oxygen, and restoring mitochondrial function. The effect ran through a defense switch called Nrf2 and a protective enzyme called GPX4. Blocking either one partly undid the benefit, marking this pathway as a candidate drug target.
Catalog record
| CREATOR | Zelin HUANG, Ming LAI, Qinglan WEI, Qi CAO, Kang CHEN, Jie ZHANG |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |