Stimuli-Responsive Calcium Phosphate Nanoreactor for Synergistic Chemo-Photothermal-Ferroptosis Therapy of Colorectal Cancer
Xinxin Zhang, Fengyuan Qian, Yixiang Huang, Bowen Zheng, Ziran Wang, Huanhuan Zhu, Bo Zhang · 2026
Read Stimuli-Responsive Calcium Phosphate Nanoreactor for Synergistic Chemo-Photothermal-Ferroptosis Therapy of Colorectal Cancer by Xinxin Zhang, Fengyuan Qian, Yixiang Huang, Bowen Zheng, Ziran Wang, Huanhuan Zhu, Bo Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13580444.txt.
Description
Colorectal cancer resists treatment through poor drug targeting, whole body toxicity, and resistance. Xinxin Zhang and co-authors built a nanoparticle designed to attack on three fronts at once. The particle is a calcium phosphate core coated with hyaluronic acid, carrying the iron compound hemin inside and the chemotherapy drug doxorubicin on its surface. It is built to fall apart in the sour surroundings of a tumor, releasing its cargo where it is needed.
In lab dishes the particles killed colorectal cancer cells better when a near infrared laser warmed them, combining drug action, heat, and ferroptosis, an iron driven cell death. In mice, the particles gathered in tumors and slowed growth more than single treatments did. They also nudged immune cells inside the tumor toward an attacking state. Safety checks showed no major organ damage or blood chemistry problems. The authors present the platform as a promising combined therapy.
Catalog record
| CREATOR | Xinxin Zhang, Fengyuan Qian, Yixiang Huang, Bowen Zheng, Ziran Wang, Huanhuan Zhu, Bo Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |