Synthesis, characterization, and integrated in silico studies of 4-Aminoantipyrine-derived Schiff bases as promising antimicrobial, antioxidant, and cytotoxic agents: DFT, ADME, and molecular docking studies
Mohammed I Sultan, Muthanna C Urabee, Ahmed H Sadiq, Ahmed Mutanabbi Abdula · 2026
Read Synthesis, characterization, and integrated in silico studies of 4-Aminoantipyrine-derived Schiff bases as promising antimicrobial, antioxidant, and cytotoxic agents: DFT, ADME, and molecular docking studies by Mohammed I Sultan, Muthanna C Urabee, Ahmed H Sadiq, Ahmed Mutanabbi Abdula (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13580057.txt.
Description
New compounds built from a known drug core are tested against germs and cancer cells in a 2026 study by Mohammed I Sultan and co-authors. The team made six Schiff base variants from 4-aminoantipyrine by joining it to a range of ring-shaped aldehydes.
Standard lab spectra confirmed the new bonds had formed as planned. All six compounds fought two tough bacterial species, with one variant clearly strongest against both. A free-radical test showed antioxidant power that swung widely with the attached groups. Three variants also killed liver cancer cells in a dose-dependent way. Computer studies modeled the compounds' shapes, body handling, and fit into target proteins, rounding out a mixed lab-and-screen case for the family.
Catalog record
| CREATOR | Mohammed I Sultan, Muthanna C Urabee, Ahmed H Sadiq, Ahmed Mutanabbi Abdula |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |