Dexamethasone reduces osteogenic potential through suppressing retinoic acid signaling via NF-κB/CYP26B1 axis in mesenchymal stem cells
Ai-Hua Ye, Yu-Mei Wang, Xin-Yue Wan, Jia Liu, Ni Tang, Wen-Ting Liu, Jie Cai, Dong-Mei He, Bai-Cheng He, Wen-Ge He, Liang Chen · 2026
Read Dexamethasone reduces osteogenic potential through suppressing retinoic acid signaling via NF-κB/CYP26B1 axis in mesenchymal stem cells by Ai-Hua Ye, Yu-Mei Wang, Xin-Yue Wan, Jia Liu, Ni Tang, Wen-Ting Liu, Jie Cai, Dong-Mei He, Bai-Cheng He, Wen-Ge He, Liang Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13579854.txt.
Description
Ai-Hua Ye and colleagues trace how a steroid drug blocks bone building in stem cells, in a 2026 study. Long steroid use is the top cause of secondary bone thinning, yet the chain of harm was fuzzy. Stem cells pushed toward bone making were dosed with a strong steroid, and a rat model of the disease backed the dish work.
The steroid lowered bone marker levels and drained the cells of retinoic acid, a signal that feeds bone growth. It did so by raising an enzyme that chews that signal up. Silencing the enzyme restored bone markers, while forcing it high erased the rescue that added signal gave. A master inflammation switch drove the enzyme's rise, and blocking that switch eased the steroid's harm. The chain gives drug hunters three linked targets.
Catalog record
| CREATOR | Ai-Hua Ye, Yu-Mei Wang, Xin-Yue Wan, Jia Liu, Ni Tang, Wen-Ting Liu, Jie Cai, Dong-Mei He, Bai-Cheng He, Wen-Ge He, Liang Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55194 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |