Doxorubicin-loaded chitosan/gold nanoparticles enhance anticancer effects and reduce CLMAT3 and ZNRD1-AS1 expression in colorectal cancer cells
Fatemeh Alizadeh, Ali Rajabi, Sina Goharmomayez, Marziyeh Fathi, Reza Safaralizadeh · 2026
Read Doxorubicin-loaded chitosan/gold nanoparticles enhance anticancer effects and reduce CLMAT3 and ZNRD1-AS1 expression in colorectal cancer cells by Fatemeh Alizadeh, Ali Rajabi, Sina Goharmomayez, Marziyeh Fathi, Reza Safaralizadeh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13579848.txt.
Description
Fatemeh Alizadeh and colleagues load a classic chemo drug into chitosan and gold nanoparticles to hit colorectal cancer harder, in a 2026 lab study. Free drug spreads through the body and harms healthy tissue. The loaded particles, checked by light and size tools, packed the drug at a high rate and stayed in the nano range suited for tumor entry.
Cancer cells took up the loaded particles more eagerly than free drug. The loaded form killed cells at a sixth of the free drug dose, pushed far more cells into programmed death, and froze the rest before division. Treated cells also crawled less in a scratch test. Two long RNA strands, raised in real tumors yet weak as diagnostic signs, fell under the loaded drug, a bonus the authors note.
Catalog record
| CREATOR | Fatemeh Alizadeh, Ali Rajabi, Sina Goharmomayez, Marziyeh Fathi, Reza Safaralizadeh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 104863 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |