Mechanistic insights into HipA‐mediated bacterial persistence: Role of initial cellular states and toxin expression kinetics
Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang · 2026
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Description
Jing Zhao and co-authors probe how a bacterial toxin creates drug-tolerant sleeper cells in a 2026 study. Such persisters survive antibiotics without true resistance and can restart infection later. The HipA toxin is a known trigger, but the cell states that favor it were less clear.
Cells just waking from rest entered the sleeper state most readily when toxin output rose. What mattered was how fast the toxin built up, not the peak level reached. A starvation signal protein proved vital to the process. The results tie toxin timing and growth phase to sleeper formation, with hints for drugs that block it.
Catalog record
| CREATOR | Jing Zhao, Yixiao Xiong, Hongxia Zhao, Jin Wang, Xiaona Fang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |