FBXO28 targets SNAI1 for ubiquitin-proteasomal degradation in non-small cell lung cancer
Jingyu Lin, Xinran Qiao, Hua Liu, Yang Chen, Zhen Li, Xinyi Tong, Mi Shen, Rui Zhang, Ying Han, Jiajia Shen, Zhen Wang · 2026
Read FBXO28 targets SNAI1 for ubiquitin-proteasomal degradation in non-small cell lung cancer by Jingyu Lin, Xinran Qiao, Hua Liu, Yang Chen, Zhen Li, Xinyi Tong, Mi Shen, Rui Zhang, Ying Han, Jiajia Shen, Zhen Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13579309.txt.
Description
Jingyu Lin and ten co-authors show that a tagging protein helps destroy a driver of lung cancer spread, in a study from 2026. The driver pushes cells to loosen and move, a step toward metastasis. It is normally short-lived because the cell tags it for disposal, but the full set of tagging agents was unclear.
The tagging protein was lower in tumor tissue than in nearby healthy tissue, and higher levels linked to better patient outlook. It binds the driver and marks it for disposal, with help from a known kinase. Blocking disposal reversed the effect. Restoring the tagger curbed cell movement in dishes and in animal models.
Catalog record
| CREATOR | Jingyu Lin, Xinran Qiao, Hua Liu, Yang Chen, Zhen Li, Xinyi Tong, Mi Shen, Rui Zhang, Ying Han, Jiajia Shen, Zhen Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |