Carrier-free nanoparticles in microneedles disrupt endosomal acidification suppress ferroptosis in radiation-induced oral mucositis
Yanxuan Xiao, Pengcheng Sun, Wenjie Xu, Xinyan Hao, Tiantian Tang, Xinying Liu, Hai Huang, Zhaojian Gong, Junyong Wu · 2026
Read Carrier-free nanoparticles in microneedles disrupt endosomal acidification suppress ferroptosis in radiation-induced oral mucositis by Yanxuan Xiao, Pengcheng Sun, Wenjie Xu, Xinyan Hao, Tiantian Tang, Xinying Liu, Hai Huang, Zhaojian Gong, Junyong Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13579284.txt.
Description
Yanxuan Xiao and eight co-workers wrote a 2026 study on a microneedle patch for mouth sores caused by radiation care. Such sores are the most common side effect of head and neck radiation. A form of iron-driven cell death feeds the damage. The team aimed to block iron uptake in mouth tissue cells.
Their patch carries tiny particles made of two standard drugs, with no extra carrier. Needle tips drop the particles into the tongue lining. Inside cell compartments, the particles block acid build-up and slow iron recycling. In rats, the patch eased ulcers and sped healing, with less swelling and better tissue growth.
Catalog record
| CREATOR | Yanxuan Xiao, Pengcheng Sun, Wenjie Xu, Xinyan Hao, Tiantian Tang, Xinying Liu, Hai Huang, Zhaojian Gong, Junyong Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |