Increased Polymicrobial Infection Rates and Associated Mortality in Patients With Chronic Gastrointestinal Disease Undergoing Antibiotic Spacer Placement for Periprosthetic Joint Infection
Julian Wier, Sahil S Telang, Pranit Kumaran, Avinash Iyer, Jay R Lieberman, Nathanael D Heckmann · 2026
Read Increased Polymicrobial Infection Rates and Associated Mortality in Patients With Chronic Gastrointestinal Disease Undergoing Antibiotic Spacer Placement for Periprosthetic Joint Infection by Julian Wier, Sahil S Telang, Pranit Kumaran, Avinash Iyer, Jay R Lieberman, Nathanael D Heckmann (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13579276.txt.
Description
Julian Wier and co-authors link gut disease to worse joint infections in a 2026 study. Infected artificial joints are treated in stages, with an antibiotic spacer holding the gap. Germs from a troubled gut may seed these infections. A national hospital database found patients who had spacer surgery after hip or knee replacement between 2016 and 2023.
Those with chronic gut disease grew more infections with several germ species at once, and died more often. Adjusted models kept joint, sex, and sickness burden in view. The gut joint axis, once a hunch, now carries outcome numbers. Surgeons may need broader early antibiotics for this group.
Catalog record
| CREATOR | Julian Wier, Sahil S Telang, Pranit Kumaran, Avinash Iyer, Jay R Lieberman, Nathanael D Heckmann |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |