Loss of Neutrophils and SLPI Reshapes Early Mucosal Inflammatory Responses During Intranasal Vaccination
Oktawia Osiecka, Mariia Tyshchenko, Ivan Sinkevich, Natalia Pocałuń, Joanna Cichy, Jakub M. Kwiecinski, Ewa Oleszycka, Mieszko M. Wilk · 2026
Read Loss of Neutrophils and SLPI Reshapes Early Mucosal Inflammatory Responses During Intranasal Vaccination by Oktawia Osiecka, Mariia Tyshchenko, Ivan Sinkevich, Natalia Pocałuń, Joanna Cichy, Jakub M. Kwiecinski, Ewa Oleszycka, Mieszko M. Wilk (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13579227.txt.
Description
Oktawia Osiecka and co-authors map the first immune moves after a nose-delivered vaccine, in a 2026 study. Nasal vaccines meet germs at their entry point, yet the early local response is poorly charted. The team used a whole-cell whooping cough vaccine in mice. Nose delivery pulled in neutrophils, a front-line cell, and spiked a guard protein called SLPI in the airway.
Mice bred without SLPI, or drained of neutrophils, told the next part. Both factors shaped local levels of agents tied to clotting and tissue reshaping. Neutrophils also tuned the first release of IgA, a key airway antibody. The picture is one of teamwork: cells and soluble guards steer the response together. The flagged agents may serve as early marks for judging new nasal vaccines.
Catalog record
| CREATOR | Oktawia Osiecka, Mariia Tyshchenko, Ivan Sinkevich, Natalia Pocałuń, Joanna Cichy, Jakub M. Kwiecinski, Ewa Oleszycka, Mieszko M. Wilk |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |